Noscapine Base is a prominent natural poppy alkaloid and a key pharmaceutical intermediate manufactured by Parand Darou Co. It serves as a vital precursor in the synthesis of Noscapine Hydrochloride and various antitussive pharmaceutical formulations.
Pharmacological Significance
Unlike other opium derivatives, Noscapine is non-narcotic, non-sedating, and non-addictive. It exerts its antitussive effects by directly suppressing the cough center in the medulla oblongata. Furthermore, it is currently gaining attention in advanced biomedical studies as a lead compound with tubulin-inhibiting properties and potential antitumor therapeutic potential.
Quality Assurance & Storage
At Parand Darou Co., Noscapine Base is synthesized under strict Quality Control (QC) supervision, meeting high-purity standards (minimum 99.0%) and adhering to internal specifications. It maintains chemical stability for at least 2 years when stored at room temperature. It is highly recommended to store the product in well-closed, moisture-proof containers.
General Information
| Product Name | Noscapine Base | |
| Chemical Name | (3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one | |
| Manufacturer | Parand Darou Co. | |
| CAS No. | 128-62-1 | |
| Pharmacopoeia | In-house |
Specification
| Molecular formula | C22H23NO7 | Sulfated ash | Max 0.5% | |||
| Molecular weight | 413.43 | Purity | Min 99.0% | |||
| Appearance | White to off-white powder | Assay | 99.0% – 100.1% (anhydrous) | |||
| Solubility | Soluble in acetone | Storage | Well-closed container | |||
| Water | Max 1.0% | Stability | Well-closed container | |||
| Water | Max 1.0% | Stability |
