Papaverine Hydrochloride is a premier Active Pharmaceutical Ingredient (API) synthesized and manufactured by Parand Darou Co. It functions as a potent antispasmodic and vasodilator, exerting a direct, non-specific relaxant effect on smooth muscle tissue. This API is essential in the formulation of various injectable and oral pharmaceutical products designed to manage vascular and muscular spasms.
Mechanism of Action & Clinical Applications
Papaverine HCl operates primarily by inhibiting the phosphodiesterase (PDE) enzyme, leading to an increase in intracellular cyclic AMP (cAMP) levels. This elevation induces the relaxation of smooth muscles in the walls of blood vessels, the gastrointestinal tract, and the biliary/urinary systems. It is extensively utilized in clinical settings to treat cerebral and peripheral vascular spasms, acute urinary tract spasms, and renal/biliary colic. Furthermore, it serves a critical role in improving perfusion and microcirculation during vascular surgery and microsurgical procedures.
Standards, Quality & Storage
Manufactured at Parand Darou under stringent Good Manufacturing Practice (GMP) guidelines, Papaverine HCl adheres to the rigorous requirements of both the United States Pharmacopeia (USP) and the British Pharmacopoeia (BP). The product features an ultra-high purity profile of at least 99.5%. To maintain potency, it must be stored in tight, light-resistant containers at controlled room temperature (25°C), ensuring chemical and physical stability for a minimum of 24 months.
General Information
| Product Name | Papaverine HCl | |
| Chemical Name | 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride | |
| Manufacturer | Parand Darou Co. | |
| CAS No. | 61-25-6 | |
| Category | Antispasmodic / Vasodilator | |
| Pharmacopoeia | USP, BP |
Specification
| Molecular formula | C20H22ClNO4 | Water | Max. 0.5% | |||
| Molecular weight | 375.9 | Sulfated ash | Max. 0.1% | |||
| Appearance | White/off-white crystalline powder | Purity | Min. 99.5% | |||
| Solubility | Sparingly sol. in water; slightly sol. in ethanol | Assay | 99.0% to 101.0% | |||
| Melting point | 146°C – 149°C | Storage | Tight, light-resistant container at 25°C | |||
| pH | 3.0 – 4.5 | Stability | Stable 2 yrs at R.T. |
