Dapagliflozin Propanediol is a cutting-edge Active Pharmaceutical Ingredient (API) belonging to the Sodium-Glucose Co-transporter 2 (SGLT2) inhibitor class, manufactured at Parand Darou Co. This API, formulated with specific propanediol monohydrate, is essential for the commercial production of medications aimed at optimal glycemic control in patients with Type 2 Diabetes, as well as for reducing the risk of heart failure and preserving renal function.
Mechanism of Action & Clinical Advantages
Dapagliflozin acts through the selective and reversible inhibition of SGLT2 transporters in the renal proximal tubules, thereby preventing the reabsorption of glucose and facilitating urinary glucose excretion (Glucosuria). This insulin-independent mechanism not only effectively lowers glycated hemoglobin (HbA1c) levels but also provides physiological benefits such as blood pressure reduction, weight management, and significant improvements in cardio-renal outcomes for patients.
Standards, Analysis & Storage
At Parand Darou, Dapagliflozin Propanediol is synthesized in strict compliance with the highest United States Pharmacopeia (USP) standards. Our API boasts an exceptional purity level of minimum 99.7% and a precisely controlled propanediol content (14.0% to 16.5%). To ensure maximum efficacy and shelf-life, the product is packaged in well-closed containers, stored at controlled room temperature, and guarantees chemical stability for at least 24 months.
General Information
| Product Name | Dapagliflozin Propanediol | |
| Chemical Name | (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol(S)-propane-1,2-diol (1:1) monohydrate | |
| Manufacturer | Parand Darou Co. | |
| CAS No. | 960404-48-2 | |
| Category | Antidiabetic (Type 2) | |
| Pharmacopoeia | USP |
Specification
| Molecular formula | C21H25ClO6 · C3H8O2 · H2O | Propanediol content | 14.0% – 16.5% | |||
| Molecular weight | 502.99 | Purity | Min. 99.7% | |||
| Appearance | White or off-white, crystalline powder | Assay | 98.0% to 102.0% (anhydrous/solvent-free) | |||
| Solubility | Freely sol. in methanol; sol. in acetonitrile; very slightly sol. in water | Storage | Well-closed container at R.T. | |||
| Water | 3.2% – 4.0% | Stability | Stable 2 yrs at R.T. |
