Buprenorphine HCl (Buprenorphine Hydrochloride) is a semi-synthetic opioid with partial agonist properties at the μ-opioid receptor and antagonist properties at the κ-opioid receptor. It is widely utilized in addiction therapy and for the management of severe pain. This Active Pharmaceutical Ingredient (API) is manufactured at Parand Darou Pharmaceutical Company, adhering to the highest quality standards and compliant with international pharmacopoeias (BP, USP, IP).
Mechanism of Action & Therapeutic Application
Due to its high affinity and partial intrinsic activity at opioid receptors, Buprenorphine creates a “Ceiling Effect,” significantly reducing the risks of respiratory depression and severe dependence compared to full agonists. This unique characteristic makes Buprenorphine HCl a safe and pivotal choice for opioid maintenance and detoxification programs, as well as chronic pain management. Our product, featuring an assay of 98.5%–101.5% and a minimum purity of 99.3%, ensures unparalleled efficacy for pharmaceutical formulations.
Physicochemical Properties & Storage
Buprenorphine HCl is supplied as a white or almost white crystalline powder. It is sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96%), and practically insoluble in cyclohexane. The specific optical rotation ranges between -92° and -98°. To ensure a stability period of at least 2 years at room temperature (R.T), the product must be stored in containers protected from direct light.
General Information
| Product Name | Buprenorphine HCl | |
| Chemical Name | (2S)-2-[17-(Cyclopropylmethyl)-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol hydrochloride | |
| Manufacturer | Parand Darou Co. | |
| CAS No. | 53152-21-9 | |
| Category | Addiction therapy | |
| Pharmacopoeia | BP, USP, IP |
Specification
| Molecular formula | C29H42ClNO4 | Specific optical rotation | -92 to -98 (dried substance) | |||
| Molecular weight | 504.1 | Sulfated ash | Max. 0.2% | |||
| Appearance | White or almost white, crystalline powder | Purity | Min. 99.3% | |||
| Solubility | Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96%), practically insoluble in cyclohexane | Assay | 98.5% to 101.5% (dried substance) | |||
| Water | Max. 1.0% | Storage | Protected from light | |||
| Heavy metals | Max. 20 ppm | Stability | Stable at least 2 years at R.T |
