Noscapine HCl is a high-solubility hydrochloride salt of the naturally derived alkaloid Noscapine, widely utilized as an Active Pharmaceutical Ingredient (API) in the manufacturing of antitussive therapeutic agents. Produced by Parand Darou Co. in strict adherence to EP, BP, and JP pharmacopoeial standards, this derivative addresses the solubility limitations of the free base form. Being non-narcotic and free from typical opioid side effects like sedation, analgesia, or dependency, it remains an essential component for the formulation of effective cough syrups, elixirs, and oral suspensions.
Mechanism of Action & Clinical Utility
Noscapine hydrochloride exerts its antitussive efficacy through direct suppression of the cough reflex center within the medulla oblongata. Furthermore, it modulates airway sensitivity by functioning as an agonist at σ (sigma) receptors and antagonizing bradykinin-induced responses, thereby preventing bronchial irritation. The hydrochloride form provides superior water and ethanol solubility compared to the base, ensuring rapid dissolution and high bioavailability in liquid oral dosage forms, making it an ideal choice for pharmaceutical applications requiring precise dosing and rapid onset.
Quality Standards & Storage Requirements
Parand Darou manufactures Noscapine HCl as a white to almost white, hygroscopic crystalline powder. Our production process ensures a purity level of 99.0% to 101.0% (calculated on the dried substance). Due to its hygroscopic nature, this API is processed and packaged under tightly controlled environmental conditions. It must be stored in airtight containers protected from light and moisture to maintain chemical integrity and physical stability for at least 2 years at ambient room temperature.
General Information
| Product Name | Noscapine HCl | |
| Chemical Name | (3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride hydrate | |
| Manufacturer | Parand Darou Co. | |
| CAS No. | 912-60-7 | |
| Category | Antitussive | |
| Pharmacopoeia | EP, BP, JP |
Specification
| Molecular formula | C19H22ClNO4·2H2O | Melting point | ~ 200 °C (dec.) | |||
| Molecular weight | 467.9 g/mol | pH | Min. 3.0 | |||
| Appearance | White/off-white crystalline powder; hygroscopic | Purity | Min. 99.0% | |||
| Solubility | Freely sol. in water/ethanol (96%). | Assay | 99.0% – 101.0% (dried) | |||
| Water | 2.5% – 6.5% | Storage | Airtight, light-protected | |||
| Rotation | +38.5 to +44.0 | Stability | Stable 2 years (R.T) |
