Codeine Base is a naturally occurring phenanthrene opioid alkaloid and a fundamental Active Pharmaceutical Ingredient (API) in the pharmaceutical industry. Manufactured by Parand Darou Co. in strict compliance with international compendial standards (BP and USP), this high-purity base serves as an essential precursor for the synthesis of various codeine salts and the formulation of finished dosage forms, primarily indicated as analgesics and antitussives.
Mechanism of Action & Clinical Indications
Codeine acts as a selective agonist at μ-opioid receptors. Its primary analgesic efficacy is achieved through its hepatic bioactivation into morphine via the cytochrome P450 enzyme CYP2D6. In addition to its moderate pain-relieving properties, codeine exerts a direct centrally-acting inhibitory effect on the medullary cough center, making it a benchmark therapeutic agent for the suppression of persistent, non-productive chronic coughs.
Quality Attributes, Purity & Storage
Parand Darou supplies Codeine Base as colorless crystals or a white crystalline powder with a verified purity profile of no less than 98.5% and an assay range of 98.5% to 100.5% (calculated on the anhydrous basis). The substance exhibits a defined melting range of 155–159 °C, with water content controlled at a maximum of 6.0%. It maintains pharmaceutical stability for at least 2 years under controlled room temperature when stored in airtight, light-resistant packaging.
General Information
| Product Name | Codeine | |
| Chemical Name | (5R,6S)-4,5α-Epoxy-3-methoxy-17-methyl-7,8-didehydromorphinan-6α-ol | |
| Manufacturer | Parand Darou Co. | |
| CAS No. | 76-57-3 | |
| Pharmacopoeia | BP, USP |
Specification
| Molecular formula | C18H21NO3 | Sulfate | Max. 0.1% | |||
| Molecular weight | 299.37 g/mol | Purity | Min. 98.5% | |||
| Appearance | Colorless or white crystals or white, crystalline powder | Assay | 98.5% to 100.5% | |||
| Solubility | Very soluble in chloroform, freely soluble in alcohol, sparingly soluble in ether, slightly soluble in water | Storage | Protected from light | |||
| Water | Max. 6.0% | Stability | Stable at least 2 years at R.T | |||
| Melting point | 155 – 159 °C |
