Noscapine Hydrochloride
| Grade | Pharmaceutical |
| Pharmacopoeia | EP, BP, JP |
| CAS No. | 912-60-7 |
| Product Name | Noscapine Hydrochloride |
| Chemical Name | (3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride hydrate |
| Function | Active Pharmaceutical Ingredients (APIs) |
| Industrial Application | Pharmaceutical |
| Category | Antitussive |
General Description
Noscapine Hydrochloride is the orally available hydrochloride salt of the opioid agonist noscapine. It is a phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy *Papaver somniferum* with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine exerts its antitussive effects through the activation of sigma opioid receptors.
Physical Characteristics
| Molecular formula | C₂₂H₂₄ClNO₇·H₂O |
| Molecular weight | 467.9 |
| Appearance | White or almost white, crystalline powder or colourless crystals, hygroscopic |
| Solubility | Freely soluble in water and in ethanol (96%). Aqueous solutions are slightly acidic; the base may precipitate if allowed to stand |
| Melting point | About 200 °C, with decomposition |
| pH | Minimum 3.0 |
| Specific optical rotation | +38.5 to +44.0 (dried substance) |
| Water | 2.5% to 6.5% (105 °C) |
| Sulfated ash | Maximum 0.1% |
| Purity | Minimum 99.0% |
| Assay | 99.0% to 101.0% (dried substance) |
| Storage | In an airtight container, protected from light |
| Stability | Stable at least 2 years at room temperature |