Noscapine
| Grade | Pharmaceutical |
| Pharmacopoeia | USP, BP, JP |
| CAS No. | 128-62-1 |
| Product Name | Noscapine |
| Chemical Name | (3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g)isoquinolin-5-yl]isobenzofuran-1(3H)-one |
| Function | Active Pharmaceutical Ingredients (APIs) |
| Industrial Applications | Pharmaceutical |
| Category | Antitussive |
General Description
Noscapine is a phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine exerts its antitussive effects through the activation of sigma opioid receptors.
Physical Characteristics
| Molecular formula | C22H23NO7 |
| Molecular weight | 413.43 |
| Appearance | White or almost white, crystalline powder or colourless crystals |
| Solubility | Freely soluble in chloroform, soluble in acetone, slightly soluble in ethanol (96%), practically insoluble in water |
| Melting point | 174 – 176 °C |
| Water | Maximum 1.0% |
| Sulfated ash | Maximum 0.1% |
| Optical rotation | +42° to +48° |
| Purity | Minimum 99.0% |
| Assay | 99.0% to 101.0% (anhydrous basis) |
| Storage | Preserve in well-closed container |
| Stability | Stable at least 2 years at R.T |