Tramadol Hydrochloride
| Grade | Pharmaceutical |
| Pharmacopoeia | USP, BP |
| CAS No. | 36282-47-0 |
| Product Name | Tramadol Hydrochloride |
| Chemical Name | (1RS,2RS)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol hydrochloride |
| Function | Active Pharmaceutical Ingredients (APIs) |
| Industrial Application | Pharmaceutical |
| Category | Pain management |
General Description
Tramadol is an opioid agonist which is used to treat moderate to severe chronic pain in adults. Extended-release form of tramadol is used for around-the-clock treatment for long-term pain management. It works on the same proteins in the brain as morphine does.
Physical Characteristics
| Molecular formula | C₁₆H₂₆ClNO₂ |
| Molecular weight | 299.8 |
| Appearance | White or almost white, crystalline powder |
| Solubility | Freely soluble in water and in methanol, very slightly soluble in acetone |
| Melting point | 180 – 184 °C |
| Water | Maximum 0.5% |
| Optical rotation | -0.10° to +0.10° |
| Sulfated ash | Maximum 0.1% |
| Content of chloride | 11.6%–12.1% |
| Residue on ignition | Maximum 0.1% |
| Purity | Minimum 99.6% |
| Assay | 99.0% to 101.0% (anhydrous substance) |
| Storage | Protected from light |
| Stability | Stable at least 2 years at room temperature |