Naltrexone Hydrochloride
| Grade | Pharmaceutical |
| Pharmacopoeia | BP, USP |
| CAS No. | 850808-02-5 |
| Product Name | Naltrexone Hydrochloride |
| Chemical Name | 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride |
| Function | Active Pharmaceutical Ingredients (APIs) |
| Industrial Application | Pharmaceutical |
| Category | Addiction therapy |
General Description
Naltrexone is an opioid antagonist used in opioid and alcohol use disorder. It reduces cravings and helps control physiological dependence. Naltrexone works by blocking the effects of alcohol and opioid medications, preventing euphoria, intoxication, and relapses.
Physical Characteristics
| Molecular formula | C₂₀H₂₄ClNO₄ |
| Molecular weight | 377.9 |
| Appearance | White or almost white powder, very hygroscopic |
| Solubility | Freely soluble in water, slightly soluble in ethanol (96%), practically insoluble in methylene chloride |
| Water | Maximum 10.0% |
| Specific optical rotation | -187 to -195 (anhydrous substance) |
| Sulfated ash | Maximum 0.1% |
| Ethanol | Maximum 3.0% |
| Content of chloride | 9.20%–9.58%, calculated on the anhydrous, solvent-free basis |
| Residue on ignition | Maximum 0.1% |
| Purity | Minimum 99.0% |
| Assay | 98.0% to 102.0% (anhydrous substance) |
| Storage | In an airtight container. Protected from light |
| Stability | Stable at least 2 years at room temperature |