Morphine Sulfate
| Grade |
Pharmaceutical |
| Pharmacopoeia |
USP, BP |
| CAS No. |
6211-15-0 |
| Product Name |
Morphine Sulfate |
| Chemical Name |
Di(7,8-didehydro-4,5α-epoxy-17-methylmorphinan-3,6α-diol) sulfate pentahydrate |
| Function |
Active Pharmaceutical Ingredients (APIs) |
| Industrial Application |
Pharmaceutical |
| Category |
Pain management |
General Description
Opioids are natural and synthetic compositions which target the mu, kappa, and delta endogenous opioid receptors.
Endogenous peptides employ pain relief intermediatory acts on these receptors.
Opioids mimic the peptide effects on these receptors.
Intensity of pain, route of administration, and duration of patient usage are criteria for selecting the appropriate opioid.
Morphine sulfate is indicated for the relief of chronic, persistent severe pain.
Physical Characteristics
| Molecular formula |
C₃₄H₄₀N₂O₁₀S·5H₂O |
| Molecular weight |
759 |
| Appearance |
White or almost white, crystalline powder |
| Solubility |
Soluble in water, very slightly soluble in ethanol (96%), practically insoluble in toluene |
| Water |
10.4% to 13.4% |
| Specific optical rotation |
-107 to -110 (anhydrous substance) |
| Residue on ignition |
Maximum 0.1% |
| Sulfated ash |
Maximum 0.1% |
| Chloride |
No precipitate or turbidity is produced immediately |
| Ammonium salts |
No odor of ammonia is perceptible |
| Iron |
Maximum 5 PPM |
| Limit of foreign alkaloids |
Not less than 7.5 mL is required (1.5%) |
| Purity |
Minimum 99.0% |
| Assay |
98.0% to 102.0% |
| Storage |
Protected from light |
| Stability |
Stable at least 2 years at room temperature |
