Methadone Hydrochloride
| Grade |
Pharmaceutical |
| Pharmacopoeia |
USP, BP |
| CAS No. |
1095-90-5 |
| Product Name |
Methadone Hydrochloride |
| Chemical Name |
(6RS)-6-(Dimethylamino)-4,4-diphenylheptan-3-one hydrochloride |
| Function |
Active Pharmaceutical Ingredients (APIs) |
| Industrial Application |
Pharmaceutical |
| Category |
Addiction therapy |
General Description
Methadone is a synthetic opioid which is the major drug used in addiction therapy and maintenance therapy.
Methadone has no metabolite. Its plasma concentration lasts 6–8 hours and increases on extended use.
Its onset effect is within 0.5–1 hour and lasts for 12 hours on extended use.
Its unique crystalline form is an added value in the manufacturing process.
Physical Characteristics
| Molecular formula |
C₂₁H₂₈ClNO |
| Molecular weight |
345.9 |
| Appearance |
White or almost white, crystalline powder |
| Solubility |
Soluble in water, freely soluble in ethanol (96%) |
| Melting point |
233 – 236 °C |
| pH |
4.5 – 6.5 |
| Water content |
Maximum 0.5% (105 °C) |
| Optical rotation |
Between -0.05° to +0.05° |
| Sulfated ash |
Maximum 0.1% |
| Purity |
Minimum 99.7% |
| Assay |
99.0% to 101.0% (dried substance) |
| Storage |
Protected from light |
| Stability |
Stable at least 2 years at room temperature |
