Codeine phosphate hemihydrate
| Grade |
Pharmaceutical |
| Pharmacopoeia |
USP, BP |
| CAS No. |
41444-62-6 |
| Product Name |
Codeine phosphate hemihydrate |
| Chemical Name |
4,5α-Epoxy-3-methoxy-17-methyl-7,8-didehydromorphinan-6α-ol phosphate hemihydrate |
| Function |
Active Pharmaceutical Ingredients (APIs) |
| Industrial Application |
Pharmaceutical |
| Category |
Analgesic, pain management |
General Description
Codeine phosphate monohydrate is from a category of opioids which target the opioid receptors.
Opioids mimic the endogenous peptide effect on the Mu, Kappa, and Delta receptors.
It is usually formulated with NSAIDs to enhance its effect in pain management.
Its crystalline form facilitates its free-flowing and easy compressibility in tabletting processes.
Physical Characteristics
| Molecular formula |
C₁₈H₂₁NO₃·H₃PO₄·1/2H₂O |
| Molecular weight |
406.4 |
| Appearance |
White or almost white, crystalline powder or small colourless crystals |
| Solubility |
Freely soluble in water, slightly soluble or very slightly soluble in ethanol (96%) |
| Melting point |
155 – 159 °C |
| pH |
4.0 – 5.0 |
| Water content |
Maximum 3.0% |
| Chloride |
No opalescence is produced immediately |
| Specific optical rotation |
-98 to -102 (dried substance) |
| Purity |
Minimum 98.0% |
| Assay |
98.5% to 101.0% (anhydrous basis) |
| Storage |
Protected from light |
| Stability |
Stable at least 2 years at room temperature |
