Codeine Monohydrate
| Grade | Pharmaceutical |
| Pharmacopoeia | USP, BP |
| CAS No. | 6059-47-8 |
| Product Name | Codeine Monohydrate |
| Chemical Name | 4,5α-Epoxy-3-methoxy-17-methyl-7,8-didehydromorphinan-6α-ol monohydrate |
| Function | Intermediate |
| Industrial Applications | Pharmaceutical |
| Category | Pain management |
General Description
Codeine monohydrate is an opioid. Codeine is derived from the poppy plant Papaver somniferum oliferra (Papaveraceae). It is used as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended for persistent dry coughing. Codeine monohydrate serves as an intermediate in pharmaceutical manufacturing.
Physical Characteristics
| Molecular formula | C18H21NO3·H2O |
| Molecular weight | 317.4 |
| Appearance | White or almost white, crystalline powder or colourless crystals |
| Solubility | Soluble in boiling water, freely soluble in ethanol (96%) |
| Melting point | 155 – 159 °C |
| Water | 4.0% to 6.0% |
| Sulfate | Maximum 0.1% |
| Purity | Minimum 98.0% |
| Assay | 99.0% to 101.0% |
| Storage | Protected from light |
| Stability | Stable at least 2 years at R.T |