Dapagliflozin Propanediol
| Grade | Pharmaceutical |
| Pharmacopoeia | USP |
| CAS No. | 960404-48-2 |
| Product Name | Dapagliflozin Propanediol |
| Chemical Name | (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (S)-propane-1,2-diol (1:1) monohydrate |
| Function | Active Pharmaceutical Ingredients (APIs) |
| Industrial Application | Pharmaceutical |
| Category | Antidiabetic type 2 |
General Description
Dapagliflozin is used to treat type 2 diabetes. It is also prescribed for adults with heart failure and chronic kidney disease. This compound reversibly inhibits sodium-glucose co-transporter 2 (SGLT-2) in the renal proximal convoluted tubule, reducing glucose reabsorption and increasing urinary glucose excretion.
Physical Characteristics
| Molecular formula | C₂₁H₂₅ClO₆·C₃H₈O₂·H₂O |
| Molecular weight | 502.99 |
| Appearance | White or off white, crystalline powder |
| Solubility | Freely soluble in methanol, soluble in acetonitrile, very slightly soluble in water |
| Water | 3.2% – 4.0% |
| Content of propanediol | 14.0% – 16.5% |
| Purity | Minimum 99.7% |
| Assay | 98.0% to 102.0% (anhydrous, propanediol-free, and solvent-free basis) |
| Storage | Preserve in a well-closed container. Store at controlled room temperature |
| Stability | Stable at least 2 years at room temperature |