{"id":1615,"date":"2025-06-08T11:44:35","date_gmt":"2025-06-08T11:44:35","guid":{"rendered":"https:\/\/paranddarou.co\/?p=1615"},"modified":"2025-06-09T05:22:38","modified_gmt":"2025-06-09T05:22:38","slug":"noscapine-hydrochloride","status":"publish","type":"post","link":"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/noscapine-hydrochloride\/","title":{"rendered":"Noscapine Hydrochloride"},"content":{"rendered":"

Noscapine Hydrochloride<\/span><\/h2>\n\n\n\n\n\n\n\n\n\n\n
Grade<\/strong><\/td>\nPharmaceutical<\/td>\n<\/tr>\n
Pharmacopoeia<\/strong><\/td>\nEP, BP, JP<\/td>\n<\/tr>\n
CAS No.<\/strong><\/td>\n912-60-7<\/td>\n<\/tr>\n
Product Name<\/strong><\/td>\nNoscapine Hydrochloride<\/td>\n<\/tr>\n
Chemical Name<\/strong><\/td>\n(3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride hydrate<\/td>\n<\/tr>\n
Function<\/strong><\/td>\nActive Pharmaceutical Ingredients (APIs)<\/td>\n<\/tr>\n
Industrial Application<\/strong><\/td>\nPharmaceutical<\/td>\n<\/tr>\n
Category<\/strong><\/td>\nAntitussive<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

General Description<\/span><\/h3>\n

Noscapine Hydrochloride is the orally available hydrochloride salt of the opioid agonist noscapine. It is a phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy *Papaver somniferum* with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine exerts its antitussive effects through the activation of sigma opioid receptors.<\/p>\n

Physical Characteristics<\/span><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Molecular formula<\/strong><\/td>\nC\u2082\u2082H\u2082\u2084ClNO\u2087\u00b7H\u2082O<\/td>\n<\/tr>\n
Molecular weight<\/strong><\/td>\n467.9<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite or almost white, crystalline powder or colourless crystals, hygroscopic<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nFreely soluble in water and in ethanol (96%). Aqueous solutions are slightly acidic; the base may precipitate if allowed to stand<\/td>\n<\/tr>\n
Melting point<\/strong><\/td>\nAbout 200 \u00b0C, with decomposition<\/td>\n<\/tr>\n
pH<\/strong><\/td>\nMinimum 3.0<\/td>\n<\/tr>\n
Specific optical rotation<\/strong><\/td>\n+38.5 to +44.0 (dried substance)<\/td>\n<\/tr>\n
Water<\/strong><\/td>\n2.5% to 6.5% (105 \u00b0C)<\/td>\n<\/tr>\n
Sulfated ash<\/strong><\/td>\nMaximum 0.1%<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\nMinimum 99.0%<\/td>\n<\/tr>\n
Assay<\/strong><\/td>\n99.0% to 101.0% (dried substance)<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nIn an airtight container, protected from light<\/td>\n<\/tr>\n
Stability<\/strong><\/td>\nStable at least 2 years at room temperature<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Noscapine Hydrochloride Grade Pharmaceutical Pharmacopoeia EP, BP, JP CAS No. 912-60-7 Product Name Noscapine Hydrochloride Chemical Name (3S)-6,7-Dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride hydrate Function Active Pharmaceutical Ingredients (APIs) Industrial Application Pharmaceutical Category Antitussive General Description Noscapine Hydrochloride is the orally available hydrochloride salt of the opioid agonist noscapine. It is a phthalide isoquinoline non-narcotic alkaloid derived from the […]<\/p>\n","protected":false},"author":1,"featured_media":970,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[134],"class_list":["post-1615","post","type-post","status-publish","format-standard","has-post-thumbnail","category-api","tag-noscapine-hydrochloride-is-the-orally-available-hydrochloride-salt-of-the-opioid-agonist-noscapine-it-is-a-phthalide-isoquinoline-non-narcotic"],"_links":{"self":[{"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/posts\/1615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/comments?post=1615"}],"version-history":[{"count":3,"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/posts\/1615\/revisions"}],"predecessor-version":[{"id":1716,"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/posts\/1615\/revisions\/1716"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/media\/970"}],"wp:attachment":[{"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/media?parent=1615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/categories?post=1615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/paranddarou.co\/index.php\/wp-json\/wp\/v2\/tags?post=1615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}