{"id":1562,"date":"2025-06-08T06:49:56","date_gmt":"2025-06-08T06:49:56","guid":{"rendered":"https:\/\/paranddarou.co\/?p=1562"},"modified":"2025-06-08T07:27:09","modified_gmt":"2025-06-08T07:27:09","slug":"codeine-phosphate-hemihydrate","status":"publish","type":"post","link":"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/","title":{"rendered":"Codeine phosphate hemihydrate"},"content":{"rendered":"
\n

Codeine phosphate hemihydrate<\/span><\/h2>\n\n\n\n\n\n\n\n\n\n\n
Grade<\/strong><\/td>\nPharmaceutical<\/td>\n<\/tr>\n
Pharmacopoeia<\/strong><\/td>\nUSP, BP<\/td>\n<\/tr>\n
CAS No.<\/strong><\/td>\n41444-62-6<\/td>\n<\/tr>\n
Product Name<\/strong><\/td>\nCodeine phosphate hemihydrate<\/td>\n<\/tr>\n
Chemical Name<\/strong><\/td>\n4,5\u03b1-Epoxy-3-methoxy-17-methyl-7,8-didehydromorphinan-6\u03b1-ol phosphate hemihydrate<\/td>\n<\/tr>\n
Function<\/strong><\/td>\nActive Pharmaceutical Ingredients (APIs)<\/td>\n<\/tr>\n
Industrial Application<\/strong><\/td>\nPharmaceutical<\/td>\n<\/tr>\n
Category<\/strong><\/td>\nAnalgesic, pain management<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

General Description<\/span><\/h3>\n

Codeine phosphate monohydrate is from a category of opioids which target the opioid receptors.
\nOpioids mimic the endogenous peptide effect on the Mu, Kappa, and Delta receptors.
\nIt is usually formulated with NSAIDs to enhance its effect in pain management.
\nIts crystalline form facilitates its free-flowing and easy compressibility in tabletting processes.<\/p>\n

Physical Characteristics<\/span><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Molecular formula<\/strong><\/td>\nC\u2081\u2088H\u2082\u2081NO\u2083\u00b7H\u2083PO\u2084\u00b71\/2H\u2082O<\/td>\n<\/tr>\n
Molecular weight<\/strong><\/td>\n406.4<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite or almost white, crystalline powder or small colourless crystals<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nFreely soluble in water, slightly soluble or very slightly soluble in ethanol (96%)<\/td>\n<\/tr>\n
Melting point<\/strong><\/td>\n155 – 159 \u00b0C<\/td>\n<\/tr>\n
pH<\/strong><\/td>\n4.0 – 5.0<\/td>\n<\/tr>\n
Water content<\/strong><\/td>\nMaximum 3.0%<\/td>\n<\/tr>\n
Chloride<\/strong><\/td>\nNo opalescence is produced immediately<\/td>\n<\/tr>\n
Specific optical rotation<\/strong><\/td>\n-98 to -102 (dried substance)<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\nMinimum 98.0%<\/td>\n<\/tr>\n
Assay<\/strong><\/td>\n98.5% to 101.0% (anhydrous basis)<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nProtected from light<\/td>\n<\/tr>\n
Stability<\/strong><\/td>\nStable at least 2 years at room temperature<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Codeine phosphate hemihydrate Grade Pharmaceutical Pharmacopoeia USP, BP CAS No. 41444-62-6 Product Name Codeine phosphate hemihydrate Chemical Name 4,5\u03b1-Epoxy-3-methoxy-17-methyl-7,8-didehydromorphinan-6\u03b1-ol phosphate hemihydrate Function Active Pharmaceutical Ingredients (APIs) Industrial Application Pharmaceutical Category Analgesic, pain management General Description Codeine phosphate monohydrate is from a category of opioids which target the opioid receptors. Opioids mimic the endogenous peptide effect […]<\/p>\n","protected":false},"author":1,"featured_media":963,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[20,1],"tags":[],"class_list":{"0":"post-1562","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-api","8":"category-uncategorized"},"acf":[],"yoast_head":"\nCodeine phosphate hemihydrate - Parand Darou Pharmaceutical Co.<\/title>\n<meta name=\"description\" content=\"Codeine phosphate monohydrate is from a category of opioids which target the opioid receptors.Opioids mimic the endogenous peptide effec\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Codeine phosphate hemihydrate\" \/>\n<meta property=\"og:description\" content=\"Codeine phosphate monohydrate is from a category of opioids which target the opioid receptors.Opioids mimic the endogenous peptide effec\" \/>\n<meta property=\"og:url\" content=\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/\" \/>\n<meta property=\"og:site_name\" content=\"Parand Darou Pharmaceutical Co.\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-08T06:49:56+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-08T07:27:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/paranddarou.co\/wp-content\/uploads\/2024\/12\/API.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1176\" \/>\n\t<meta property=\"og:image:height\" content=\"972\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Website Administrator\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Website Administrator\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/\"},\"author\":{\"name\":\"Website Administrator\",\"@id\":\"https:\/\/paranddarou.co\/#\/schema\/person\/fde8a6d2d638681a7618b45fd3f07265\"},\"headline\":\"Codeine phosphate hemihydrate\",\"datePublished\":\"2025-06-08T06:49:56+00:00\",\"dateModified\":\"2025-06-08T07:27:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/\"},\"wordCount\":173,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/paranddarou.co\/#organization\"},\"image\":{\"@id\":\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/paranddarou.co\/wp-content\/uploads\/2024\/12\/API.webp\",\"articleSection\":[\"2.API\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/\",\"url\":\"https:\/\/paranddarou.co\/index.php\/2025\/06\/08\/codeine-phosphate-hemihydrate\/\",\"name\":\"Codeine phosphate hemihydrate - 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